Inflammatory bowel disease

The main difference between Crohn's disease and UC is the location and nature of the inflammatory changes. Crohn's can affect any part of the gastrointestinal tract, from mouth to anus (skip lesions), although a majority of the cases start in the terminal ileum. Ulcerative colitis, in contrast, is restricted to the colon and the rectum.[4]
Pathophysiology in Crohn's disease vs. ulcerative colitis
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Crohn's disease Ulcerative colitis
Autoimmune disease Widely regarded as
an autoimmune disease No consensus
Cytokine response Associated with Th17[5] Vaguely associated with Th2
Microscopically, ulcerative colitis is restricted to the mucosa (epithelial lining of the gut), while Crohn's disease affects the whole bowel wall ("transmural lesions").

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Removals Oxford